Study shows mammographic density reduction as a prognostic marker of improved survival

Mammographic Density Reduction Is a Prognostic Marker of Response to Adjuvant Tamoxifen Therapy in Postmenopausal Patients With Breast Cancer Tamoxifen treatment is associated with a reduction in mammographic density and an improved survival. However, the extent to which change in … Continue reading

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Unique study reveals genetic spelling mistakes that increase the risk of common cancers

[Press release, 27 March 2013] More than 80 genetic ’spelling mistakes’ that can increase the risk of breast, prostate and ovarian cancer have been found in a large, international research study within the framework of the EU Network COGS. For the first time, the … Continue reading

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Launching Karma Normal to study mammographic density in healthy women

In a substudy to Karma, scientists will study why it is more common among women with high mammographic density to develop breast cancer. The study will investigate breast tissue biopsies from women with low breast density and compare this with … Continue reading

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50,000 women participates in the Karma study

Breast cancer has steadily increased over the past 40 years. In Sweden, one woman per hour is diagnosed with breast cancer and every six hours a woman dies from the disease. The need to prevent the onset of breast cancer … Continue reading

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High-throughput mammographic density measurement: a tool for risk prediction of breast cancer

Mammographic density (MD) is a strong, independent risk factor of breast cancer, but measuring MD is time-consuming and reader-dependent. Objective MD measurement in a high-throughput fashion would enable its wider use as a biomarker for breast cancer. We use a … Continue reading

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The genomic and transcriptomic architecture of 2,000 breast tumours reveals novel subgroups

The elucidation of breast cancer subgroups and their molecular drivers requires integrated views of the genome and transcriptome from representative numbers of patients. We present an integrated analysis of copy number and gene expression in a discovery and validation set … Continue reading

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19p13.1 is a triple negative-specific breast cancer susceptibility locus

The 19p13.1 breast cancer susceptibility locus is a modifier of breast cancer risk in BRCA1 mutation carriers and is also associated with risk of ovarian cancer. Here we investigated 19p13.1 variation and risk of breast cancer subtypes, defined by estrogen … Continue reading

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Genome-wide association analysis identifies three new breast cancer susceptibility loci

Breast cancer is the most common cancer among women. To date, 22 common breast cancer susceptibility loci have been identified accounting for ∼8% of the heritability of the disease. We attempted to replicate 72 promising associations from two independent genome-wide … Continue reading

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Karma Research Platform (beta) up and running.

The Karma Research Platform (beta) is now up and running. As of today, any scientist with sound science can get access to the world’s best-characterized breast cancer cohort. “We are proud to present the Karma Research Platform. With more than … Continue reading

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