Doctoral student Shadi Azam has recently published two papers investigating mammographic density change using the KARMA cohort.
In a first paper studying the determinants of change, Azam and colleagues conclude that most risk factors for breast cancer are associated with baseline mammographic density. In contrast, only age, BMI and physical activity are determinants of mammographic density change.
In a second paper, Azam et al. suggest that, although mammographic density is a strong risk factor for breast cancer, mammographic density change does not influence breast cancer risk. Furthermore, density change does not seem to influence the association between baseline mammographic density and breast cancer risk.
The papers can be found at:
Azam S, Sjölander A, Eriksson M, Gabrielson M, Czene K, Hall P.
JNCI Cancer Spectr. 2019 Feb 4;3(1):pkz004. doi: 10.1093/jncics/pkz004. eCollection 2019 Mar.
Azam S, Eriksson M, Sjölander A, Hellgren R, Gabrielson M, Czene K, Hall P
J Natl Cancer Inst. 2019 Jul 12. pii: djz149. doi: 10.1093/jnci/djz149.