The association between annual mammographic density change and breast cancer risk was evaluated using the Karma Cohort (N = 43 810). Density was measured using the STRATUS method and relative mammographic density change was categorized as decreased (>10% decrease per year), stable (no change), or increased (>10% increase per year). Cox proportional hazards regression was used to estimate the association.
In all, 563 women were diagnosed with breast cancer but no significant association between mammographic density change and breast cancer was seen. Adding baseline mammographic density did not influence the results.
Mammographic Density Change and Risk of Breast Cancer. Azam et al. Journal of the National Cancer Institute. DOI: 10.1093/jnci/djz149