The Karma Cohort

The Karma Cohort is a prospective screening cohort consisting of 70,877 women, initiated in 2011 [Gabrielson, 2017]. Participating women have donated blood that is stored at the Karolinska Institutet Biobank []. Participating women have also repeatedly answered a detailed questionnaire and allowed matching to health care registers and medical records. Every time a participant preforms a mammogram the images are stored. Current rate is approximately 25,000 images / month. Approximately 20,000 Karma participants have been genotyped with the iCOGS or Oncoarry chip as part of a collaboration with the Breast Cancer Association Consortium [as an example please see Michailidou, 2017]. For a detailed description of the Karma Cohort, please see [Gabrielson 2017].

Gabrielson M, Eriksson M, Hammarström M, Borgquist S, Leifland K, Czene K, Hall P. Cohort profile: The KarolinskaMammography Project for Risk Prediction of Breast Cancer (KARMA).Int J Epidemiol. 2017 Feb 9. doi: 10.1093/ije/dyw357. PMID: 2818025

Michailidou K, .., Czene K, ..Hall P, ….., Easton DF. Association analysis identifies 65 new breast cancer risk loci.Nature. 2017 Oct 23. doi: 10.1038/nature24284.